Mitochondrial Health and Chronic Fatigue: Why Cellular Energy Matters
- Lesley Nickleson, RD, IFNCP
- Jun 5
- 3 min read

Chronic fatigue? I have been there with total exhaustion that no amount of sleep could reverse. And it wasn't just feeling tired, it felt like every cell in body was drained. What finally helped me to turn it around? My Integrative Functional Nutrition training and adopting a lifestyle that support deep cellular healing and repair.
For me, having abundant energy is my top health priority— it’s what drives everything I do. I never want to go back to that burned-out version of myself again. If you can relate to this feeling, it is time to explore mitochondrial health as the hidden key to energy and vitality.
What Is Mitochondrial Health and Why Is It Important?
Mitochondria are often called the “powerhouses” of your cells and for good reason. These cellular structures are responsible for producing ATP -adenosine triphosphate, the body’s form of energy. In short, they make the energy that fuels everything your body does from thinking clearly to regulating hormones to burning fat.
When your mitochondria are healthy, you feel energetic, focused and strong, able to get through your day with ease and then some. But when mitochondria are not functioning optimaly, everything slows down. That is when symptoms like chronic fatigue, brain fog, mood swings, and metabolic issues start to show up.
How Poor Mitochondrial Health Leads to Chronic Fatigue
If you’ve been struggling with low energy, it is a potential root cause that your mitochondria are under-functioning and it is not your fault. Mitochondrial dysfunction can be caused by many modern-day stressors: poor nutrition, chronic stress, lack of sleep, toxin exposure and inflammation. Our mitochondrial function naturally decline with age. When mitochondria are unable to meet the body’s energy demands, you begin to feel the effects in every system of your body.
You might notice that you wake up tired, crash mid-afternoon or feel like your brain is constantly in a fog. You might even feel emotionally flat or have trouble recovering after exercise. These symptoms are more than just “busy life” or aging: they are signs your body is asking for cellular support.
How to Improve Mitochondrial Health with Functional Nutrition
In my work as a Functional Practitioner, I help clients support and repair mitochondrial function with targeted food and lifestyle strategies. Instead of reaching for more coffee or supplements, we look at what the mitochondria actually need to thrive.
That includes key nutrients like B vitamins, magnesium, CoQ10 and antioxidants — all of which can be provided through a balanced, anti-inflammatory diet rich in colourful whole foods. We also explore lifestyle strategies starting with improving sleep, breathwork, reducing toxic load, managing stress, and creating gentle movement routines that support, rather than deplete energy.
Functional nutrition takes a root-cause approach. Rather than managing fatigue at the surface level, we address the deeper systems driving it — starting at the cellular level.
Signs You Might Have Mitochondrial Dysfunction
If your mitochondria are not working well, you may experience:
Persistent fatigue, even after rest
Brain fog or forgetfulness
Blood sugar crashes or cravings
Slower metabolism or weight loss resistance
Muscle weakness, aches and pains
Low mood, irritability or lack of motivation
These are all signs your body is working hard just to keep up — and your cells may need deeper support.
Cellular Energy Is the Foundation of Vitality
Real energy doesn’t come from sugar, caffeine or pushing through. It comes from strong, supported mitochondria. Whether you are dealing with chronic fatigue, hormonal shifts, or burnout, optimizing mitochondrial health can transform how you feel and how you feel day to day.
If you’re ready to reclaim your energy and restore vitality from the root, I invite you to explore how Functional Nutrition can support you. Let’s build a plan that nourishes your body at the cellular level and helps you feel truly well again.
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