Functional Nutrition Guide: 7 -Step Nutritional Detox Plan
- Lesley Nickleson, RD, IFNCP
- May 29
- 5 min read
Updated: Jun 5

Introduction: Why Detox?
Detoxification is not a trend—it is a nutrient-dependent biological process that happens in your body every single day. Your liver, kidneys, skin, lungs and lymphatic system are constantly working to neutralize, transform, and eliminate toxins. But when your toxin load exceeds your body's natural ability to clear them, symptoms can build up like unexplained fatigue, brain fog, joint pain, skin breakouts and unusual rashes and digestive issues.
A true detox isn't about deprivation—it's about nourishment with strategic support. The goal is to optimize your body's built-in detox pathways so they can optimize their function.
The 3 Phases of Detoxification
Phase 1: Activation: Enzymes in the liver begin breaking down toxins, converting them into intermediate compounds. These compounds can be even more reactive and damaging, so this phase requires strong antioxidant support to prevent cellular damage.
Phase 2: Conjugation: This phase involves pairing those activated compounds with molecules (like amino acids, sulfur, and glutathione) to neutralize them and make them water-soluble so they can be excreted.
Phase 3: Elimination (Excretion): Once neutralized, the toxins are transported out of the body via urine, stool, breath, or sweat. This step depends on your “emunctories”—your body’s pathways of elimination—and is often overlooked in most detox plans.
7-Step Nutriotional Detox Plan
Step 1: Prime the Pathways – The PreTox to DeTox
Jumping straight from a diet full of processed food, caffeine or alcohol into a deep detox can be overwhelming and stressful for your body. That’s why a PreTox phase is essential. For 1–2 weeks before your detox:
Remove added sugar, alcohol, processed food, and chemical additives.
Reduce caffeine gradually.
Begin to Add: colourful, fiber-rich plants, antioxidant-rich foods and high-quality proteins.
PreTox helps your body transition, reduces the intensity of detox symptoms,like headaches, fatigue, skin breakouts, and ensures your detox runs smoothly.
Step 2: Open the Emunctories
Your emunctories—or elimination pathways including the liver, kidneys, lymph, skin, colon, lungs—are the exit doors for toxins. If these doors are congested, toxins recirculate.
Support your emunctories with:
Daily movement : walking, yoga, rebounding
Dry brushing to stimulate lymph flow
Oil pulling to support oral detox
Breathwork and fresh air for lung detox
Regular bowel movements to ensure waste elimination
Step 3: Focus on a Whole Food, Nutrient-Dense Diet
Begin a whole food, nutrient nutrition plan on Day 1 of your detox. The foundation of a healthy detox is what you eat. It is essential to include cruciferous vegetables every day- like broccoli, kale, cauliflower or Brussels sprouts daily to support both Phase 1 and Phase 2 detoxification. These vegetables enhance liver enzyme activity and increase glutathione, one of your body's master antioxidants.
A high-quality protein intake is also critical for Phase 2. Organic eggs, legumes, wild-caught fish, and pastured meats supply amino acids like glycine, cysteine, and methionine—building blocks required for detoxification conjugation reactions.
Supportive nutrients like B vitamins (especially B6, B12, folate), magnesium, selenium, zinc, and glutathione precursors all play pivotal roles in cellular detoxification and energy production.
Aiming for 25 to 30 grams of fiber daily from legumes, berries, seeds like chia and flax, leafy greens, and colourful vegetables helps move toxins through the colon and out of your body.
Step 4: Eliminate the Inputs: Minimize Toxin Exposures
During the process it is critical to minimize your toxin exposure while you are trying to clear them.
Choose organic when possible. Prioritize the Clean Fifteen.
Read ingredient labels—remove foods with chemical additives, artificial sweeteners, preservatives and food colouring.
Switch to natural personal care and cleaning products
Filter your water and avoid plastic water bottles & containers
Step 5: Bind and Clear: Binders
Begin taking binders and slowly increase your dose during the detox journey. This step is often the most overlooked—but it’s one of the most critical. When your body begins to mobilize stored toxins from fat tissue, those toxins need to be captured and escorted out of the body. That’s where binders come in.
Binders act like magnets—binding to toxins in the digestive tract and helping eliminate them through the stool. Without them, toxins may get reabsorbed into the bloodstream, causing detox reactions like headaches, fatigue, skin flare-ups, or digestive upset.
Some of the most effective binders include:
Fulvic and Humic Acids: These naturally occurring organic compounds improve cellular detoxification by binding to heavy metals and pesticides, while also helping shuttle nutrients into cells.
Modified Citrus Pectin (PectaSol): My personal favourite. This clinically studied binder grabs onto heavy metals and environmental toxins without depleting minerals. It’s gentle, effective, and well-tolerated for long-term use.
Diatomaceous Earth: A natural powder rich in silica, which can support detox by binding to bacteria, parasites, and other pathogens in the gut.
Other supportive binders include bentonite clay, activated charcoal, chlorella, and zeolite.
Always take binders away from food, medications or supplements, and under the guidance of a knowledgeable practitioner.
Step 6: Hydrate and Flow
Water is the delivery system that helps your cells detox. Aim for 2–3 liters of clean fluids per day.
Add electrolytes or freshly squeezed lemon for extra support
Include herbal teas like dandelion, nettle or milk thistle to aid detox
Prepare homemade broth
Step 7: Listen to Your Body – Know the Detox Signs and Symptoms
Detox symptoms can vary and are often a sign that your body is shifting and releasing stored toxins. Common signs include:
Headaches or fatigue
Irritability or mood changes
Skin breakouts or rashes
Digestive changes -bloating, loose stools, constipation
Brain fog
Muscle aches and joint pains
These symptoms are typically temporary. If they persist or intensify, it may indicate that your detox needs to be adjusted, slowed down or more strongly supported. Working with a practitioner can help tailor your detox to your unique needs.
How Long Should a Detox Last?
While quick fixes are often advertised, meaningful detoxification takes time. I typically recommend a 28-day detox journey. This gives your body adequate time to prepare, mobilize, eliminate and reset. Shorter detoxes can support seasonal tune-ups, but for deeper detoxification and lasting results, a full month provides the best results.
Who Is a Detox For?
In my Integrative Functional Nutrition, Metabolic Detoxification was one of the most fascinating modules. It is recommended in conditions involving autoimmunity, mitochondrial disorders, chronic fatigue syndrome and fibromyalgia. In addition, it can be used for anyone looking to reduce inflammation, improve energy, support hormone balance, enhance digestion, and feel more vibrant. If you're dealing with fatigue, brain fog, adverse food reactions and sensitivities, skin issues, slow metabolism, or frequent illness, your body may be signaling the need for a deeper reset.
Always consult with a qualified practitioner, especially if you have underlying conditions, are pregnant or nursing, or are taking medications.
Final Thoughts
Detoxification is not a quick fix or a one-size-fits-all program. It’s a strategic, layered process that supports your body’s natural ability to heal and thrive.
When done properly—with preparation, nourishment, and lifestyle support—a nutritional detox can reset your system, clear inflammation and dramatically improve how you feel
If you are interested in a detox journey, I can help. Please feel free to reach out and inquire about my 28-Day Detox program that you can be guided through.
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